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Fumagillin

Cat. No. 1768 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1768 has been discontinued.

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说明： Methionine aminopeptidase-2 inhibitor; antiangiogenic
化学名： (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Fumagillin

Fumagillin is an antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.

技术数据 for Fumagillin

分子量 458.55
公式 C26H34O7
储存 Store at -20°C
CAS Number 23110-15-8
PubChem ID 6917655
InChI Key NGGMYCMLYOUNGM-CSDLUJIJSA-N
Smiles [H][C@@]1([C@]3(C)[C@@H](C/C=C(C)/C)O3)[C@@]2(CO2)CC[C@@H](OC(/C=C/C=C/C=C/C=C/C(O)=O)=O)[C@H]1OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Fumagillin

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Fumagillin

参考文献是支持产品生物活性的出版物。

Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153 PMID: 9770455

Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555 PMID: 1701033

Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327 PMID: 4630977

Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457 PMID: 11848509

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关键词: Fumagillin, Fumagillin supplier, Methionine, aminopeptidase-2, inhibitors, inhibits, Proteases, Proteinases, antiangiogenics, angiogenesis, antibiotics, Antiangiogenics, Antibiotics, Aminopeptidases, 1768, Tocris Bioscience

1 篇 Fumagillin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Fumagillin 的部分引用包括：

Palmer et al (2012) A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol 165 1891 PMID: 21943108

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