主页 / 药理学 / Enzymes / Transferases / Protein Arginine Methyltransferases / Protein Arginine Methyltransferase Inhibitors / Furamidine dihydrochloride

Furamidine dihydrochloride

Cat. No. 5202 5 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective PRMT1 inhibitor
化学名： 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (5)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Furamidine dihydrochloride

Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits tyrosyl-DNA phosphodiesterase 1 (TDP-1) (IC50 = 1.2 μM). Inhibits cell proliferation in leukemia cell lines, suppresses neuroblastoma tumor growth, and reduces mis-splicing in in vitro and in vivo models of myotonic dystrophy type 1. Also shows dose-dependent inhibition of platelet aggregation (IC50 = 14.8 uM). Cell-permeable.

化合物库 for Furamidine dihydrochloride

Furamidine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Furamidine dihydrochloride

分子量 377.27
公式 C18H16N4O.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 55368-40-6
PubChem ID 462428
InChI Key VXNYQUQHOUERTR-UHFFFAOYSA-N
Smiles NC(C(C=C3)=CC=C3C1=CC=C(C2=CC=C(C(N)=N)C=C2)O1)=N.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Furamidine dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 18.86 50
DMSO 18.86 50

制备储备液 for Furamidine dihydrochloride

以下数据基于产品分子量 377.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.3 mL 26.51 mL 53.01 mL
2.5 mM 1.06 mL 5.3 mL 10.6 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
25 mM 0.11 mL 0.53 mL 1.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for Furamidine dihydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Furamidine dihydrochloride

参考文献是支持产品生物活性的出版物。

Yan et al (2014) Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J.Med.Chem. 57 2611 PMID: 24564570

Jenquin et al (2018) Furamidine rescues myotonic dystrophy type I associated mis-splicing through multiple mechanisms. ACS Chem.Biol. 13 2708 PMID: 30118588

Hua et al (2020) PRMT1 promotes neuroblastoma cell survival through ATF5. Oncogenesis 9 50 PMID: 32415090

Marsden et al (2021) Inhibition of arginine methylation impairs platelet function. ACS Pharmacol.Transl.Sci. 4 1567 PMID: 34661075

If you know of a relevant reference for Furamidine dihydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Protein Arginine Methyltransferase Inhibitors

关键词: Furamidine dihydrochloride, Furamidine dihydrochloride supplier, Selective, protein, arginine, methyltransferase, 1, PRMT1, inhibitors, inhibits, leukemia, coactivator-associated, tdp1, tyrosyl, DNA, topoisomerase, Protein, Arginine, Methyltransferases, Phosphodiesterases, 5202, Tocris Bioscience

5 篇 Furamidine dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Furamidine dihydrochloride 的部分引用包括：

Samuel et al (2018) Inhibiting Arginine Methylation as a Tool to Investigate Cross-Talk with Methylation and Acetylation Post-Translational Modifications in a Glioblastoma Cell Line. Proteomes 6 44 PMID: 30347783

Jer-Yen et al (2022) PRMT1 is an important factor for medulloblastoma cell proliferation and survival. Biochem Biophys Rep 32 101364 PMID: 36237442

Tang et al (2022) A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. Cell Rep. 38 110417 PMID: 35196489

Min-Jung et al (2020) TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes. FEBS Lett 594 2923-2930 PMID: 32767856

Marsden et al (2021) Inhibition of Arginine Methylation Impairs Platelet Function. ACS Pharmacol.Transl.Sci 4 1567 PMID: 34661075

您是否知道使用了 Tocris Furamidine dihydrochloride 的优秀论文？ 请告知我们.

Furamidine dihydrochloride 的评论

目前没有该产品的评论。 Be the first to review Furamidine dihydrochloride and earn rewards!

Have you used Furamidine dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.