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FzM1.8

Cat. No. 6961 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Frizzled 4 allosteric agonist; exhibits biased signaling; preserves stemness
化学名： 3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FzM1.8

FzM1.8 is a frizzled 4 allosteric agonist (pEC50 = 6.4). Potentiates the β-catenin pathway in the absence of any WNT ligand, by biasing FZD4 signaling toward the FZD4/PI3K axis. Preserves stemness and promotes proliferation of undifferentiated cells.

化合物库 for FzM1.8

FzM1.8 is also offered as part of the Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for FzM1.8

分子量 322.32
公式 C18H14N2O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2204290-85-5
PubChem ID 137553171
InChI Key XGNNCRZDDAJBFU-UHFFFAOYSA-N
Smiles OC(=O)C1=CC(O)=CC(NC(=O)NC2=CC3=C(C=CC=C3)C=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FzM1.8

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.23 100

制备储备液 for FzM1.8

以下数据基于产品分子量 322.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.03 mL
5 mM 0.62 mL 3.1 mL 6.21 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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参考文献 for FzM1.8

参考文献是支持产品生物活性的出版物。

Riccio et al (2018) A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist. Biochemistry 57 839 PMID: 29293331

If you know of a relevant reference for FzM1.8, please let us know.

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关键词: FzM1.8, FzM1.8 supplier, WNT, receptor, frizzled, 4, allosteric, agonists, agonism, preserves, stemness, β-catenin, FzM18, Beta-catenin, Stem, Cell, Proliferation, 6961, Tocris Bioscience

篇 FzM1.8 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Pathways for FzM1.8

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.