Galiellalactone

Name: Galiellalactone
Brand: Tocris Bioscience
SKU: 6218

Cat. No. 6218 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6218 has been discontinued.

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说明： STAT3 inhibitor; active in vivo

化学名： (4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one

纯度： ≥95% (HPLC)

说明书

引用文献

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for Galiellalactone

Galiellalactone is a STAT3 inhibitor. Irreversibly binds STAT3 and inhibits binding to DNA. Inhibits IL-6-dependent JAK/STAT signaling. Induces cell-cycle arrest in G₂/M phase and apoptosis in androgen-insensitive prostate cancer cells via activation of ATM/ATR pathway. Also destabilizes microtubules and inhibits cell migration. Exhibits anticancer effects in a mouse tumor xenograft model.

技术数据 for Galiellalactone

分子量	194.23
公式	C₁₁H₁₄O₃
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	133613-71-5
PubChem ID	3698011
InChI Key	SOIISBQQYAGDKM-UHFFFAOYSA-N
Smiles	[H][C@@]12CC[C@]3(OC(C([C@@]23O)=C[C@H](C1)C)=O)[H]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Galiellalactone

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Galiellalactone

参考文献是支持产品生物活性的出版物。

Don-Doncow et al (2014) Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J.Biol.Chem. 289 15969 PMID: 24755219

Weilder et al (2000) Inhibition of interleukin-6 signaling by galiellalactone. FEBS Lett. 484 1 PMID: 11056211

Garcia et al (2016) Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. Oncotarget 7 4490 PMID: 26683224

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关键词: Galiellalactone, Galiellalactone supplier, STAT3, inhibitors, inhibits, IL-6, signaling, anticancer, in, vivo, active, STAT, 6218, Tocris Bioscience

篇 Galiellalactone 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Galiellalactone 的引用文献。