Genistein

Cat. No. 1110 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： EGFR kinase inhibitor. Also estrogen and PPARγ ligand

化学名： 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

纯度： ≥98% (HPLC)

引用文献 (10)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Genistein

Genistein is a phytoestrogen with a wide range of biological actions. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase, binds to PPARγ and estrogen receptors and acts as an agonist at GPER. Genistein inhibits aggregation and fibrilization of Aβ₄₂ and amylin₃₇ (hiAPP). In Huntington's disease fibroblast cells, Genistein reduces intracellular mutant huntingtin (mHTT) aggregates and induces degradation of mHTT; in a cellular model of Huntington's disease, Genistein corrects the mutant phenotype through stimulation of autophagy.

化合物库 for Genistein

Genistein is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Genistein

分子量	270.24
公式	C₁₅H₁₀O₅
储存	Desiccate at -20°C
纯度	≥98% (HPLC)
CAS Number	446-72-0
PubChem ID	5280961
InChI Key	TZBJGXHYKVUXJN-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=C1)C1=COC2=C(C(O)=CC(O)=C2)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Genistein

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO		100

制备储备液 for Genistein

以下数据基于产品分子量 270.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.7 mL	18.5 mL	37 mL
5 mM	0.74 mL	3.7 mL	7.4 mL
10 mM	0.37 mL	1.85 mL	3.7 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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产品说明书 for Genistein

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Genistein

参考文献是支持产品生物活性的出版物。

Akiyama et al (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J.Biol.Chem. 262 5592 PMID: 3106339

Dang et al (2003) Peroxisome proliferator-activated receptor γ (PPARγ) as a molecular target for the soy phytoestrogen genistein. J.Biol.Chem. 278 962 PMID: 12421816

Linassier et al (1990) Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity. Biochem.Pharmacol. 39 187 PMID: 2153378

Migita et al (1994) Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors. J.Immunol. 153 3457 PMID: 7523495

Merck Index 12 4395

Ren et al (2018) Genistein: A Dual Inhibitor of Both Amyloid β and Human Islet Amylin Peptides. ACS.Chem.Neurosci. 9 1215 PMID: 29432676

Pierzynowska et al (2019) Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington's disease patients. Metab.Brain Dis. 34 PMID: 30850940

If you know of a relevant reference for Genistein, please let us know.

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