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Submit ReviewGIT 27
说明： Immunomodulator; reduces production of pro-inflammatory cytokines
化学名： 4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
纯度： ≥98% (HPLC)
生物活性 for GIT 27
GIT 27 is an orally active immunomodulatory agent that primarily targets macrophages. Inhibits TNF-α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. Also reduces the secretion of pro-inflammatory cytokines IL1-β, IL-10 and IFN-γ. Antidiabetogenic; prevents IL-β and IFN-γ-induced pancreatic islet cell death in vitro.
化合物库 for GIT 27
GIT 27 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for GIT 27
| 分子量 | 205.21 |
| 公式 | C11H11NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 6501-72-0 |
| PubChem ID | 10798271 |
| InChI Key | MUFJHYRCIHHATF-UHFFFAOYSA-N |
| Smiles | O=C(CC1CC(C2=CC=CC=C2)=NO1)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GIT 27
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 20.52 | 100 |
制备储备液 for GIT 27
以下数据基于产品分子量 205.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.87 mL | 24.37 mL | 48.73 mL |
| 5 mM | 0.97 mL | 4.87 mL | 9.75 mL |
| 10 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.97 mL |
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产品说明书 for GIT 27
参考文献 for GIT 27
参考文献是支持产品生物活性的出版物。
Stosic-Grujicic et al (2007) A potent immunomodulatory compound (S,R)-3-phenyl-4,5-dihydro-5-isoxasoleacetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of stre J.Pharmacol.Exp.Ther. 320 1038 PMID: 17148780
Stojanovic et al (2007) In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: Modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin.Immunol. 123 311 PMID: 17449326
Mangano et al (2008) In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027. Eur.J.Pharmacol. 586 313 PMID: 18374912
If you know of a relevant reference for GIT 27, please let us know.
关键词: GIT 27, GIT 27 supplier, Interfers, TLR4, TLR2/6, signalling, Immunomodulators, reduces, production, pro-inflammatory, cytokines, Toll-like, Receptors, TNF-α, TNF-alpha, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, GI, 3270, Tocris Bioscience
1 篇 GIT 27 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GIT 27 的部分引用包括：
Saurus et al (2015) Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway. Cell Death Dis 6 e1752 PMID: 25950482
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