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Submit ReviewGR 89696 fumarate
说明： Subtype-selective κ agonist
化学名： 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
纯度： ≥99% (HPLC)
生物活性 for GR 89696 fumarate
GR 89696 fumarate is a highly potent and selective κ-opioid agonist (IC50 = 0.04 nM) that may be selective for the putative κ2 receptor. Anti-nociceptive and neuroprotective in vivo.
化合物库 for GR 89696 fumarate
GR 89696 fumarate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for GR 89696 fumarate
| 分子量 | 530.4 |
| 公式 | C19H25Cl2N3O3.C4H4O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 126766-32-3 |
| PubChem ID | 6442840 |
| InChI Key | ABTNETSDXZBJTE-WLHGVMLRSA-N |
| Smiles | [H]OC(=O)\C=C\C(=O)O[H].COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)CC1=CC=C(Cl)C(Cl)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GR 89696 fumarate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 13.26 | 25 温和加热 | |
| DMSO | 53.04 | 100 |
制备储备液 for GR 89696 fumarate
以下数据基于产品分子量 530.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.89 mL | 9.43 mL | 18.85 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.89 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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产品说明书 for GR 89696 fumarate
参考文献 for GR 89696 fumarate
参考文献是支持产品生物活性的出版物。
Birch et al (1991) Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br.J.Pharmacol. 103 1819 PMID: 1657267
Butelman et al (2001) GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys. J.Pharmacol.Exp.Ther. 298 1049 PMID: 11504802
Naylor et al (1993) A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines. J.Med.Chem. 36 2075 PMID: 8393489
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关键词: GR 89696 fumarate, GR 89696 fumarate supplier, Subtype-selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, GR89696, fumarate, Kappa, Opioid, 1483, Tocris Bioscience
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