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GS 441524

Cat. No. 7227 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide
化学名： (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GS 441524

GS 441524 is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and broad spectrum antiviral nucleotide; active metabolite of Remdesivir (Cat. No. 7226). Competes with natural nucleoside triphosphates, blocking viral RNA synthesis. Exhibits antiviral activity against viruses from Coronaviridae family including SARS-CoV-2 in vitro, and SARS-CoV and feline infectious peritonitis virus (FIPV) in vitro and in vivo. Inhibits SARS-CoV and MERS-CoV- infected HAE cultures (EC50 values are 0.18 and 0.86 μM, respectively) and inhibits murine hepatitis virus (MHV) (EC50 = 1.1 μM).

化合物库 for GS 441524

GS 441524 is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GS 441524

分子量 291.27
公式 C12H13N5O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1191237-69-0
PubChem ID 44468216
InChI Key BRDWIEOJOWJCLU-LTGWCKQJSA-N
Smiles OC[C@H]1O[C@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GS 441524

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.13 100

制备储备液 for GS 441524

以下数据基于产品分子量 291.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.17 mL 34.33 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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参考文献 for GS 441524

参考文献是支持产品生物活性的出版物。

Agostini et al (2018) Coronavirus susceptibility to the antiviral Remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease mBio. 9 e00221 PMID: 29511076

Cho et al (2012) Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides Bioorg.Med.Chem.Lett. 22 2705 PMID: 22446091

If you know of a relevant reference for GS 441524, please let us know.

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关键词: GS 441524, GS 441524 supplier, GS441524, Viral, RNA-dependent, RNA, polymerase, RdRp, inhibitors, inhibits, coronaviridae, coronaviruses, SARS-CoV-2, feline, infectious, peritonitis, virus, FIPV, Polymerase, COVID-19, Coronavirus, Non-selective, Antivirals, 7227, Tocris Bioscience

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