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Submit ReviewGSK 137647
说明： Potent and selective FFA4 (GPR120) agonist
化学名： 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
纯度： ≥99% (HPLC)
生物活性 for GSK 137647
GSK 137647 is a potent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614 (Cat. No. 5256).
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
化合物库 for GSK 137647
GSK 137647 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for GSK 137647
| 分子量 | 305.39 |
| 公式 | C16H19NO3S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 349085-82-1 |
| PubChem ID | 743974 |
| InChI Key | FQUAFMNPXPXOJE-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=CC(C)=C1NS(C2=CC=C(OC)C=C2)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GSK 137647
参考文献 for GSK 137647
参考文献是支持产品生物活性的出版物。
Sparks et al (2014) Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 24 3100 PMID: 24881566
Martin et al (2012) Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity. J.Lipid Res. 53 2256 PMID: 22904345
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关键词: GSK 137647, GSK 137647 supplier, GSK137647, Free, fatty, acid, receptor, 4, diabetes, potent, and, selective, FFA4, GPR120, agonist, Fatty, Acid, Receptors, 5257, Tocris Bioscience
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