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Submit ReviewGSK J5 HCl
说明： Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
化学名： N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester hydrochloride
纯度： ≥98% (HPLC)
生物活性 for GSK J5 HCl
GSK J5 HCl is an inactive isomer of GSK J4 (Cat. No. 4594); also cell permeable ester derivative of the inactive control, GSK J2 (Cat. No. 4688).
Active Analog also available.
许可信息
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details of GSK J5, a cell permeable inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.
化合物库 for GSK J5 HCl
GSK J5 HCl is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for GSK J5 HCl
| 分子量 | 453.97 |
| 公式 | C24H27N5O2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1797983-32-4 |
| PubChem ID | 126456082 |
| InChI Key | QQHQMHJAOKADED-UHFFFAOYSA-N |
| Smiles | O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)OCC.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GSK J5 HCl
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 22.7 | 50 |
制备储备液 for GSK J5 HCl
以下数据基于产品分子量 453.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.41 mL | 22.03 mL | 44.06 mL |
| 2.5 mM | 0.88 mL | 4.41 mL | 8.81 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.41 mL |
| 25 mM | 0.09 mL | 0.44 mL | 0.88 mL |
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产品说明书 for GSK J5 HCl
参考文献 for GSK J5 HCl
参考文献是支持产品生物活性的出版物。
Kruidenier et al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488 404 PMID: 22842901
If you know of a relevant reference for GSK J5 HCl, please let us know.
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关键词: GSK J5 HCl, GSK J5 HCl supplier, GSKJ5, HCl, histone, demethylases, inhibitors, inhibits, UTX, JMJD3, KDM6, H3K27, epigenetics, Histone, Demethylases, 6935, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.