GSK LSD 1 dihydrochloride

Cat. No. 5361 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective LSD1 inhibitor

化学名： rel-N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GSK LSD 1 dihydrochloride

GSK LSD 1 dihydrochloride is a potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC₅₀ = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.

化合物库 for GSK LSD 1 dihydrochloride

GSK LSD 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK LSD 1 dihydrochloride

分子量	289.24
公式	C₁₄H₂₀N₂.2HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	2102933-95-7
PubChem ID	91663353
InChI Key	PJFZOGMSPBHPNS-WICJZZOFSA-N
Smiles	C1(N[C@@H]2C[C@H]2[C@]3=CC=CC=C3)CCNCC1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK LSD 1 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	28.92	100
	DMSO	28.92	100

制备储备液 for GSK LSD 1 dihydrochloride

以下数据基于产品分子量 289.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.46 mL	17.29 mL	34.57 mL
5 mM	0.69 mL	3.46 mL	6.91 mL
10 mM	0.35 mL	1.73 mL	3.46 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

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产品说明书 for GSK LSD 1 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GSK LSD 1 dihydrochloride

参考文献是支持产品生物活性的出版物。

If you know of a relevant reference for GSK LSD 1 dihydrochloride, please let us know.

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关键词: GSK LSD 1 dihydrochloride, GSK LSD 1 dihydrochloride supplier, GSKLSD1, dihydrochloride, potent, selective, lysine, specific, demethylases, LSD1, inhibitors, inhibits, SGC, structural, genomics, consortium, histone, Histone, Demethylases, 5361, Tocris Bioscience

1 篇 GSK LSD 1 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK LSD 1 dihydrochloride 的部分引用包括：

Ping et al (2022) Targeting histone demethylase LSD1 for treatment of deficits in autism mouse models. Mol Psychiatry 27 3355-3366 PMID: 35296809

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