GSK LSD 1 dihydrochloride

Pricing Availability   Qty
说明: Potent and selective LSD1 inhibitor
化学名: rel-N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)

生物活性 for GSK LSD 1 dihydrochloride

GSK LSD 1 dihydrochloride is a potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.

化合物库 for GSK LSD 1 dihydrochloride

GSK LSD 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK LSD 1 dihydrochloride

分子量 289.24
公式 C14H20N2.2HCl
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 2102933-95-7
PubChem ID 91663353
InChI Key PJFZOGMSPBHPNS-WICJZZOFSA-N
Smiles C1(N[C@@H]2C[C@H]2[C@]3=CC=CC=C3)CCNCC1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK LSD 1 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 28.92 100
DMSO 28.92 100

制备储备液 for GSK LSD 1 dihydrochloride

以下数据基于产品分子量 289.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.46 mL 17.29 mL 34.57 mL
5 mM 0.69 mL 3.46 mL 6.91 mL
10 mM 0.35 mL 1.73 mL 3.46 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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产品说明书 for GSK LSD 1 dihydrochloride

分析证书/产品说明书
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参考文献 for GSK LSD 1 dihydrochloride

参考文献是支持产品生物活性的出版物。

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查看全部 Histone Demethylase Inhibitors

关键词: GSK LSD 1 dihydrochloride, GSK LSD 1 dihydrochloride supplier, GSKLSD1, dihydrochloride, potent, selective, lysine, specific, demethylases, LSD1, inhibitors, inhibits, SGC, structural, genomics, consortium, histone, Histone, Demethylases, 5361, Tocris Bioscience

1 篇 GSK LSD 1 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK LSD 1 dihydrochloride 的部分引用包括:

Ping et al (2022) Targeting histone demethylase LSD1 for treatment of deficits in autism mouse models. Mol Psychiatry 27 3355-3366 PMID: 35296809


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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.