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Submit ReviewH2L 5765834
说明： LPA1,3,5 antagonist
化学名： 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid
纯度： ≥99% (HPLC)
生物活性 for H2L 5765834
H2L 5765834 is an antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 values are 94, 463 and 752 nM respectively). Exhibits no effect at LPA2 or LPA4 receptors.
化合物库 for H2L 5765834
H2L 5765834 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for H2L 5765834
| 分子量 | 404.33 |
| 公式 | C21H12N2O7 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 420841-84-5 |
| PubChem ID | 1365686 |
| InChI Key | HFYPTENHTPNXGP-UHFFFAOYSA-N |
| Smiles | O=C2N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C(C1=CC(C(O)=O)=CC=C12)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for H2L 5765834
参考文献 for H2L 5765834
参考文献是支持产品生物活性的出版物。
Williams et al (2009) Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J.Biol.Chem. 284 17304 PMID: 19366702
Fells et al (2010) 2D binary QSAR modeling of LPA3 receptor antagonism. J.Mol.Graph Model. 28 828 PMID: 20356772
Tigyi (2010) Aiming drug discovery at lysophosphatidic acid targets. Br.J.Pharmacol. 161 241 PMID: 20735414
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关键词: H2L 5765834, H2L 5765834 supplier, H2L5765834, lysophosphatidic, acid, receptors, LPA1, LPA3, LPA5, antagonists, Lysophosphatidic, Acid, Receptors, 4870, Tocris Bioscience
2 篇 H2L 5765834 的引用文献
引用文献是使用了 Tocris 产品的出版物。 H2L 5765834 的部分引用包括：
Kittaka et al (2017) Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1. J Physiol 595 2681 PMID: 28176353
Travis J et al (2023) Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs. Sci Rep 13 2864 PMID: 36806315
H2L 5765834 的评论
平均评分: 5 (Based on 1 Review.)
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H2L 5765834 inhibits LPA induced COX-2 expression in osteosarcoma cells.
By
Christopher Trummer on 10/23/2018
分析类型： In Vitro
种属： Human
细胞系/组织： Osteosarcoma
MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot. H2L inhibited COX-2 expression induced by LPA.
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