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说明： STAT5-SUMO protein-protein interaction inhibitor
化学名： 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
纯度： ≥98% (HPLC)
生物活性 for HODHBt
HODHBt is a STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (TCM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir in vitro.
技术数据 for HODHBt
| 分子量 | 163.14 |
| 公式 | C7H5N3O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 28230-32-2 |
| PubChem ID | 73026 |
| InChI Key | HJBLUNHMOKFZQX-UHFFFAOYSA-N |
| Smiles | ON1N=NC2=CC=CC=C2C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for HODHBt
参考文献 for HODHBt
参考文献是支持产品生物活性的出版物。
Bosque et al (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Rep. 18 1324 PMID: 28147284
关键词: HODHBt, HODHBt supplier, STAT5, SUMO, SUMOylation, protein-protein, interactions, inhibitors, inhibits, HIV-1, reservoir, STAT, HIV, 6994, Tocris Bioscience
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