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Submit ReviewHydroxychloroquine sulfate
说明： Autophagy inhibitor; also TLR9 inhibitor
化学名： 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
纯度： ≥99% (HPLC)
生物活性 for Hydroxychloroquine sulfate
Hydroxychloroquine sulfate is an autophagy inhibitor. Also inhibits TLR9. Inhibits growth and induces apoptosis of renal cancer cells in vitro. Additionally inhibits PRC2 by inhibiting the allosteric binding of PRC2 to EED (embryonic ectoderm development) within the H3K27me3-binding pocket, and reduces H3K27me3 levels in multiple myeloma cells in vitro. Inhibits SARS-CoV-2 viral infection, in vitro (EC50 values in μM range and dependent on viral RNA copy number). Hydroxychloroquine improves efficacy of adeno-associated viral gene transduction in vivo and in vitro. Also antimalarial and immunomodulator.
Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
技术数据 for Hydroxychloroquine sulfate
| 分子量 | 433.95 |
| 公式 | C18H28ClN3O5S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 747-36-4 |
| PubChem ID | 12947 |
| InChI Key | JCBIVZZPXRZKTI-UHFFFAOYSA-N |
| Smiles | ClC(C=C1)=CC2=C1C(NC(CCCN(CC)CCO)C)=CC=N2.OS(=O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Hydroxychloroquine sulfate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 43.4 | 100 |
制备储备液 for Hydroxychloroquine sulfate
以下数据基于产品分子量 433.95。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.3 mL | 11.52 mL | 23.04 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.61 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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产品说明书 for Hydroxychloroquine sulfate
参考文献 for Hydroxychloroquine sulfate
参考文献是支持产品生物活性的出版物。
Lee et al (2015) Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS ONE 10 e0131464 PMID: 26134285
Lamphier et al (2014) Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol.Pharmacol. 85 429 PMID: 24342772
Catalano et al (2019) A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine. Eur.J.Med.Chem. 183 PMID: 31550663
Liu et al (2020) Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery 6 16 PMID: 32194981
Chandler et al (2019) Enhancement of adeno-associated virus-mediated gene therapy using hydroxychloroquine in murine and human tissues. Mol.Ther.Methods Clin.Dev. 14 77 PMID: 31309129
If you know of a relevant reference for Hydroxychloroquine sulfate, please let us know.
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关键词: Hydroxychloroquine sulfate, Hydroxychloroquine sulfate supplier, TLR9, toll-like, receptors, inhibitors, autophagy, inhibits, cancer, immunomodulator, antimalarial, PRC2, polycomb, repressive, complex, EED, aav, viral, gene, transduction, transducer, adeno-associated, virus, Toll-like, Receptors, Autophagy, Other, Lysine, Methyltransferases, COVID-19, Endocytosis, Antimalarials, Coronavirus, Viral, Transduction, Enhancers, 5648, Tocris Bioscience
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Hydroxychloroquine sulfate 的评论
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Apoptosis induction.
By
MARINA KOUTSIOUMPA on 10/13/2022
分析类型： In Vitro
种属： Human
Combinatorial treatments of hydroxychloroquine sulfate with chemotherapeutics led to synergistic apoptotic phenotype in vitro.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Autophagy Scientific Review
Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.
Autophagy Poster
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.