IBG3 最新

Cat. No. 8129 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent molecular glue Degrader of BRD4 and BRD2 bromodomains

化学名： tert-Butyl 2-((S)-4-(4-((4'-((S)-6-(2-(tert-butoxy)-2-oxoethyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-[1,1'-biphenyl]-4-carboxamido)methyl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

文献 (1)

生物活性 Scientific Data 技术数据溶解性计算器说明书参考文献

生物活性 for IBG3

IBG3 is a very potent JQ1-containing molecular glue Degrader of BET bromodomains BRD4 and BRD2 (DC₅₀ values are 6.7 pM and 8.6 pM respectively). Induces proximity between BRD4 and DCAF16 to form a ternary complex (EC₅₀ = 32 nM).

Scientific Data

In vitro assay

View Larger

Published vs Bio-Techne batch comparison for IBG3. Endogenous HiBiT-BRD4 HEK293 cells were plated at a density of 20,000 cell per well in 100 µL of DMEM (10% FBS) in a white-walled 96 well plate and left overnight to adhere at 37 ºC, 5% CO₂. Cells were incubated in 50 µL of 10 nM-0.1 pM of IBG3 or vehicle control (DMSO) in Optimem (10% FBS) and left for 4 hours. Cells were then treated with HiBIT Lytic assay reagent– and plates were then read on a BMG Pherastar plate reader for luminescence detection. Data kindly provided by the Ciulli laboratory, University of Dundee.

技术数据 for IBG3

分子量	976.23
公式	C₅₄H₅₇N₉O₅S₂
储存	Store at -20°C
PubChem ID	171037958
InChI Key	MRIUQCAXSFYTQZ-YATWDLPUSA-N
Smiles	CC1=C(SC2=C1C(C3=CC=C(C=C3)C4=CC=C(C=C4)C(NCC5=CC=C(C6=N[C@H](C7=NN=C(N7C8=C6C(C)=C(S8)C)C)CC(OC(C)(C)C)=O)C=C5)=O)=N[C@H](C9=NN=C(N92)C)CC(OC(C)(C)C)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for IBG3

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	97.62	100

制备储备液 for IBG3

以下数据基于产品分子量 976.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.02 mL	5.12 mL	10.24 mL
5 mM	0.2 mL	1.02 mL	2.05 mL
10 mM	0.1 mL	0.51 mL	1.02 mL
50 mM	0.02 mL	0.1 mL	0.2 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for IBG3

分析证书/产品说明书

化学品安全技术说明书

参考文献 for IBG3

参考文献是支持产品生物活性的出版物。

Hsia et al (2024) Targeted protein degradation via intramolecular bivalent glues. Nature 627 204 PMID: 38383787

If you know of a relevant reference for IBG3, please let us know.

按标靶查看相关产品

关键词: IBG3, IBG3 supplier, molecular, glue, degrader, degraders, degrades, BRD2, BRD4, bromodomain, bromodomains, DCAF16, induced, proximity, JQ1, Molecular, Glues, 8129, Tocris Bioscience

篇 IBG3 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 IBG3 的引用文献。您是否知道使用了 Tocris IBG3 的优秀论文？请告知我们.

IBG3 的评论

目前没有该产品的评论。 Be the first to review IBG3 and earn rewards!

Have you used IBG3?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product GuideUpdated

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

Active Degraders
TAG Degradation Platform
Degrader Building Blocks
Assays for Protein Degradation
Induced Proximity Tools