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ICI 199,441 hydrochloride

Cat. No. 0778 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent κ agonist
化学名： 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ICI 199,441 hydrochloride

ICI 199,441 hydrochloride is a highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.

许可信息

Sold with the permission of AstraZeneca UK Ltd.

化合物库 for ICI 199,441 hydrochloride

ICI 199,441 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ICI 199,441 hydrochloride

分子量 427.8
公式 C21H24Cl2N2O.HCl
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 115199-84-3
PubChem ID 3082717
InChI Key VFLWVWZSDBTGQJ-VEIFNGETSA-N
Smiles ClC1=C(Cl)C=C(CC(N([C@@]([H])([C@]3=CC=CC=C3)CN2CCCC2)C)=O)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ICI 199,441 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100
ethanol 50

制备储备液 for ICI 199,441 hydrochloride

以下数据基于产品分子量 427.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.69 mL 23.38 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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产品说明书 for ICI 199,441 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for ICI 199,441 hydrochloride

参考文献是支持产品生物活性的出版物。

Barlow et al (1991) Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 34 3149 PMID: 1659636

Costello et al (1991) 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 34 181 PMID: 1846918

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关键词: ICI 199,441 hydrochloride, ICI 199,441 hydrochloride supplier, Potent, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, ICI199441, hydrochloride, AstraZeneca, Kappa, Opioid, 0778, Tocris Bioscience

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