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iMAC2

Cat. No. 3794 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3794 has been discontinued.

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说明： Suppressor of mitochondrial apoptosis
化学名： 3,6-Dibromo-9-[2-fluoro-3-(1-piperazinyl)propyl]-9H-carbazole dihydrochloride
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for iMAC2

iMAC2 is an inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).

技术数据 for iMAC2

分子量 542.11
公式 C19H20Br2FN3.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 335166-00-2
PubChem ID 90488878
InChI Key JWCVUOLQOHIRML-UHFFFAOYSA-N
Smiles BrC(C=C3)=CC1=C3N(CC(F)CN4CCNCC4)C2=C1C=C(Br)C=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for iMAC2

参考文献是支持产品生物活性的出版物。

Bombrun et al (2003) 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 4365 PMID: 14521400

Peixoto et al (2009) MAC inhibitors suppress mitochondrial apoptosis. Biochem.J. 423 381 PMID: 19691447

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关键词: iMAC2, iMAC2 supplier, MAC, inhibitor, mitochondrial, apoptosis-induced, channel, inhibitors, inhibits, reduces, apoptosis, bax, Other, Apoptosis, Bcl-2, Family, 3794, Tocris Bioscience

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for iMAC2

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.