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Description: Monovalent IAP antagonist
Chemical Name: (2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-phenoxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
Purity: ≥97% (HPLC)
Biological Activity for CST 530
CST 530 is a monovalent IAP antagonist. Induces potent cIAP1 autodegradation and mild cIAP2 depletion. CST 530 reduces cell viability in a variety of cancer cell lines including SUDHL6, MOLM13 and HEL (IC50 values are 170 nM, 420 nM and 450 nM respectively).
Technical Data for CST 530
| M. Wt | 560.74 |
| Formula | C33H44N4O4 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 847137-53-5 |
| InChI Key | GUOVHJVNYPRNQS-SHUILBLCSA-N |
| Smiles | CN[C@@H](C)C(N[C@@H](C1CCCCC1)C(N2[C@@H](C[C@@H](C2)OC3=CC=CC=C3)C(N[C@H]4C5=CC=CC=C5CCC4)=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CST 530
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.07 | 100 |
Preparing Stock Solutions for CST 530
The following data is based on the product molecular weight 560.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.78 mL | 8.92 mL | 17.83 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.57 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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Product Datasheets for CST 530
References for CST 530
References are publications that support the biological activity of the product.
Ng et al (2023) Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. J.Med.Chem. 66 4703 PMID: 36996313
If you know of a relevant reference for CST 530, please let us know.
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Keywords: CST 530, CST 530 supplier, CST530, inhibitor, of, apoptosis, IAP, antagonist, autodegradation, cell, viability, cIAP1, cIAP2, potent, Inhibitor, Apoptosis, (IAP), Ubiquitin, E3, Ligases, 8065, Tocris Bioscience
Citations for CST 530
Citations are publications that use Tocris products.
Currently there are no citations for CST 530. Do you know of a great paper that uses CST 530 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for CST 530
