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Isoginkgetin

Cat. No. 6483 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Pre-mRNA splicing inhibitor; cell permeable
化学名： 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Isoginkgetin

Isoginkgetin is a pre-mRNA splicing inhibitor (IC50 ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeable

技术数据 for Isoginkgetin

分子量 566.51
公式 C32H22O10
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 548-19-6
PubChem ID 5318569
InChI Key HUOOMAOYXQFIDQ-UHFFFAOYSA-N
Smiles COC1=CC=C(C2=CC(C3=C(C=C(C(C4=CC(C5=CC(C6=C(C=C(C=C6O5)O)O)=O)=CC=C4OC)=C3O2)O)O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Isoginkgetin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 56.65 100

制备储备液 for Isoginkgetin

以下数据基于产品分子量 566.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.83 mL 17.65 mL
5 mM 0.35 mL 1.77 mL 3.53 mL
10 mM 0.18 mL 0.88 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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产品说明书 for Isoginkgetin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Isoginkgetin

参考文献是支持产品生物活性的出版物。

O'Brien et al (2008) The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J.Biol.Chem. 283 33147 PMID: 18826947

Szewczak et al (2017) The right tool for the job. Cell 169 561 PMID: 28475886

Boswell et al (2017) Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Nat.Chem.Biol. 13 501 PMID: 28263964

If you know of a relevant reference for Isoginkgetin, please let us know.

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关键词: Isoginkgetin, Isoginkgetin supplier, mRNA, splicing, inhibitors, inhibits, cell-permeable, spliceosomes, transcriptional, elongation, DNA,, RNA, and, Protein, Synthesis, 6483, Tocris Bioscience

1 篇 Isoginkgetin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Isoginkgetin 的部分引用包括：

Sharon A et al (2021) Alternative splicing is a developmental switch for hTERT expression. Mol Cell 81 2349-2360.e6 PMID: 33852895

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