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Submit ReviewIspinesib
说明： High affinity and selective allosteric KSP inhibitor
别名： SB 715992
化学名： N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide
纯度： ≥98% (HPLC)
生物活性 for Ispinesib
Ispinesib is a high affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app = 1.7 nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro. Induces tumor regression of breast cancer cell xenografts in mice.
化合物库 for Ispinesib
Ispinesib is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Ispinesib
| 分子量 | 517.06 |
| 公式 | C30H33ClN4O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 336113-53-2 |
| PubChem ID | 6851740 |
| InChI Key | QJZRFPJCWMNVAV-HHHXNRCGSA-N |
| Smiles | O=C2N(CC3=CC=CC=C3)C([C@@H]([C@@H](C)C)N(CCCN)C(C4=CC=C(C)C=C4)=O)=NC1=CC(Cl)=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ispinesib
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 51.71 | 100 | |
| ethanol | 51.71 | 100 |
制备储备液 for Ispinesib
以下数据基于产品分子量 517.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.93 mL | 9.67 mL | 19.34 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.87 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.93 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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产品说明书 for Ispinesib
参考文献 for Ispinesib
参考文献是支持产品生物活性的出版物。
Lad et al (2008) Mechanism of inhibition of human KSP by ispinesib. Biochemistry 47 3576 PMID: 18290633
Davis et al (2006) Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer 6 22 PMID: 16433906
Purcell et al (2010) Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin.Cancer Res. 16 566 PMID: 20068098
If you know of a relevant reference for Ispinesib, please let us know.
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关键词: Ispinesib, Ispinesib supplier, SB715992, CK0238273, high, affinity, selective, potent, allosteric, kinesin, spindle, protein, KSP, hsEG5, SB, 715992, Kinesin, 5408, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets