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JLK 6

Cat. No. 2677 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2677 has been discontinued.

说明： Inhibitor of γ-secretase-mediated βAPP processing
化学名： 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
纯度： ≥99% (HPLC)
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引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for JLK 6

JLK 6 is an inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC50 ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β.

技术数据 for JLK 6

分子量 225.63
公式 C10H8ClNO3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 62252-26-0
PubChem ID 3803
InChI Key AMDGKLWVCUXONP-UHFFFAOYSA-N
Smiles COC1=C(Cl)C2=CC=C(N)C=C2C(=O)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for JLK 6

参考文献是支持产品生物活性的出版物。

Petit et al (2001) New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage. Nat.Cell.Biol. 3 507 PMID: 11331880

Petit et al (2003) JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo. J.Neurosci.Res. 74 370 PMID: 14598313

Hellstrom et al (2007) DII4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445 776 PMID: 17259973

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关键词: JLK 6, JLK 6 supplier, inhibitors, inhibits, γ-secretase, gamma-secretase, mediated, βAPP, betaAPP, processing, Proteinases, Proteases, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, beta, Peptides, JLK6, amyloidbeta, amyloidb, amyloidβ, Gamma-Secretase, Amyloid, Beta, 2677, Tocris Bioscience

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