Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewJMV 390-1
说明： Inhibits multiple neurotensin and neuromedin N degrading enzymes
化学名： N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-isoleucyl-L-leucine
生物活性 for JMV 390-1
Inhibitor of the major neurotensin and neuromedin N degrading enzymes (IC50 values are 31, 40, 52 and 58 nM for endopeptidase 24.15, endopeptidase 24.11, leucine aminopeptidase and endopeptidase 24.16 respectively). Exhibits analgesic effects in various nociception assays.
技术数据 for JMV 390-1
| 分子量 | 449.54 |
| 公式 | C23H35N3O6 |
| 序列 | XIL (Modifications: X-1 = N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]) |
| 储存 | Store at -20°C |
| CAS Number | 148473-36-3 |
| PubChem ID | 5487524 |
| InChI Key | MWZOULASPWUGJJ-NFBUACBFSA-N |
| Smiles | O=C(N[C@@H]([C@H](CC)C)C(N[C@@H](CC(C)C)C(O)=O)=O)[C@H](CC1=CC=CC=C1)CC(NO)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JMV 390-1
参考文献 for JMV 390-1
参考文献是支持产品生物活性的出版物。
Doulut et al (1993) Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J.Med.Chem. 36 1369 PMID: 8496905
Kitabgi et al (1992) Effects of thiorphan, bestatin and a novel metallopeptidase inhibitor JMV 390-1 on the recovery of neurotensin and neuromedin N released from mouse hypothalamus. Neurosci.Lett. 142 200 PMID: 1454216
Menard et al (1996) The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors. Biochem.J. 320 687 PMID: 8973585
按产品操作查看相关产品
关键词: JMV 390-1, JMV 390-1 supplier, JMV390-1, endopeptidases, 24.15, 24.11, 24.16, inhibitors, inhibits, neurotensin, neuromedin, n, analgesics, Other, Proteases, 2575, Tocris Bioscience
JMV 390-1 的评论
目前没有该产品的评论。 Be the first to review JMV 390-1 and earn rewards!
Have you used JMV 390-1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image