主页 / 药理学 / Enzymes / Proteases / Matrix Metalloproteases / Matrix Metalloprotease Inhibitors / JNJ 0966

JNJ 0966

Cat. No. 6439 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Pro-MMP9 activation inhibitor
化学名： N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JNJ 0966

JNJ 0966 is a pro-MMP9 activation inhibitor (IC50 = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.

化合物库 for JNJ 0966

JNJ 0966 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JNJ 0966

分子量 360.45
公式 C16H16N4O2S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 315705-75-0
PubChem ID 1117189
InChI Key ZADCDCMLLGDCRM-UHFFFAOYSA-N
Smiles COC1=C(C=CC=C1)NC2=NC(C3=C(N=C(S3)NC(C)=O)C)=CS2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JNJ 0966

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.02 50

制备储备液 for JNJ 0966

以下数据基于产品分子量 360.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.55 mL 27.74 mL 55.49 mL
2.5 mM 1.11 mL 5.55 mL 11.1 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
25 mM 0.11 mL 0.55 mL 1.11 mL

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参考文献 for JNJ 0966

参考文献是支持产品生物活性的出版物。

Scannevin et al (2017) Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J.Biol.Chem. 292 17963 PMID: 28860188

If you know of a relevant reference for JNJ 0966, please let us know.

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关键词: JNJ 0966, JNJ 0966 supplier, JNJ0966, Pro-MMP9, activation, inhibitor, zymogen, MMP9, signaling, brain, penetrant, cell, invasion, EAE, experimental, autoimmune, encephalomyelitis, matrix, metalloprotease, Matrix, Metalloprotease, 6439, Tocris Bioscience

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