JTE 013

Cat. No. 2392 20 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： S1P₂ receptor antagonist

化学名： 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide

纯度： ≥98% (HPLC)

引用文献 (20)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for JTE 013

JTE 013 is a sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P₂ (EDG-5). Inhibits S1P binding to human S1P₂ receptors with an IC₅₀ value of 17.6 nM. At concentrations up to 10 μM, displays 4.2% inhibition of S1P₃ and does not antagonize S1P₁. Enhances S1P-induced angiogenesis in vivo.

化合物库 for JTE 013

JTE 013 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JTE 013

分子量	408.29
公式	C₁₇H₁₉N₇OCl₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	383150-41-2
PubChem ID	10223146
InChI Key	RNSLRQNDXRSASX-UHFFFAOYSA-N
Smiles	CC(C)C1=C2C(C)=NN(C)C2=NC(NNC(=O)NC2=CC(Cl)=NC(Cl)=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JTE 013

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	40.83	100
	ethanol	40.83	100

制备储备液 for JTE 013

以下数据基于产品分子量 408.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.25 mL	24.49 mL
5 mM	0.49 mL	2.45 mL	4.9 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for JTE 013

分析证书/产品说明书

化学品安全技术说明书

参考文献 for JTE 013

参考文献是支持产品生物活性的出版物。

Ohmori et al (2003) Spingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. Cardiovasc.Res. 58 170 PMID: 12667959

Parrill et al (2004) Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands. Semin.Cell.Dev.Biol. 15 467 PMID: 15271292

Inoki et al (2006) Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor. Biochem.Biophys.Res.Comm. 346 293

If you know of a relevant reference for JTE 013, please let us know.

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Sphingosine-1-Phosphate Receptors

关键词: JTE 013, JTE 013 supplier, S1P2, receptor, antagonists, Receptors, EDG5, Sphingosine-1-Phosphate, JTE013, Sphingosine-1-phosphate, 2392, Tocris Bioscience