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K 114

Cat. No. 3144 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Amyloid fibril-specific fluorescent probe. Used for: amyloid fibril detection. Application: fluorescence microscopy, confocal microscopy
化学名： 4,4'-[(2-Bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for K 114

Key information: K 114 is a potent amyloid fibril-specific fluorescent probe (EC50 = 20 - 30 nM).

Used for: amyloid fibril detection.

Application: fluorescence microscopy, confocal microscopy.

Properties and Photophysical Data: K 114 exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of Aβ (1-40), α-synuclein and tau in situ. K 114 fluorescence is ph-dependent. Excitation and emission maxima (λ) are 370nm and 450 nm, respectively, at pH 8.5; excitation and emission maxima (λ) are 395nm and 520 nm, respectively, at pH 10.5.

技术数据 for K 114

分子量 393.27
公式 C22H17BrO2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 872201-12-2
PubChem ID 44828481
InChI Key OXPHQQMZTXMEGO-RJTULKDBSA-N
Smiles OC(C=C3)=CC=C3/C=C/C1=CC(Br)=C(/C=C/C2=CC=C(O)C=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for K 114

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.33 100
ethanol 19.66 50

制备储备液 for K 114

以下数据基于产品分子量 393.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.43 mL
5 mM 0.51 mL 2.54 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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产品说明书 for K 114

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for K 114

参考文献是支持产品生物活性的出版物。

Crystal et al (2003) A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J.Neurochem. 86 1359 PMID: 12950445

LeVine (2005) Mechanism of Aβ(1-40) fibril-induced fluorescence of (trans-trans)-1-bromo-2,5-bis(4-hydroxystyryl)benene (K114). Biochemistry 44 15937 PMID: 16313197

Stepanchuk et al (2021) Complex photophysical properties of K114 make for a versatile fluorescent probe for amyloid detection. ACS Chem.Neurosci. 12 1273 PMID: 33705095

If you know of a relevant reference for K 114, please let us know.

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关键词: K 114, K 114 supplier, Amyloid, fibril-specific, fluorescent, dye, Fluorescent, Probes, Beta, Precursor, Protein, APP, Secretase, β-Amyloid, beta-Amyloid, b-amyloid, Peptides, K114, amyloidbeta, amyloidb, amyloidβ, B, 3144, Tocris Bioscience

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Fluorescent Dyes and Probes Research Product Guide

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