K 22

Cat. No. 7338 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Inhibits coronavirus RNA replication; impairs double membrane vesicle (DMV) formation

化学名： N-[(1Z)-1-[[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-2-phenylethenyl]benzamide

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for K 22

K 22 is a viral RNA synthesis inhibitor; targets membrane-bound coronaviral RNA replication by inhibiting double membrane vesicle (DMV) formation. Inhibits HCoV-229E infection of MRC-5 cells in a plaque forming assay (IC₅₀ = 0.7 μM). Also inhibits HCoV-229E and MERS-CoV replication in human airway epithelia cultures.

技术数据 for K 22

分子量	505.41
公式	C₂₇H₂₅BrN₂O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2141978-86-9
PubChem ID	5433970
InChI Key	CMBUSPXASRNJHI-CLCOLTQESA-N
Smiles	OC1(C2=CC=C(Br)C=C2)CCN(C(/C(=C/C3=CC=CC=C3)/NC(=O)C4=CC=CC=C4)=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for K 22

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	50.54	100

制备储备液 for K 22

以下数据基于产品分子量 505.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.89 mL	19.79 mL
5 mM	0.4 mL	1.98 mL	3.96 mL
10 mM	0.2 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for K 22

分析证书/产品说明书

化学品安全技术说明书

参考文献 for K 22

参考文献是支持产品生物活性的出版物。

Lundin et al (2014) Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus. PLoS Pathog. 10 e1004166 PMID: 24874215

If you know of a relevant reference for K 22, please let us know.

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关键词: K 22, K 22 supplier, K22, double, membrane, vesicle, DMV, RNA, synthesis, inhibitors, inhibits, coronavirus, coronaviruses, SARS-CoV, MERS-CoV, middle, east, respiratory, syndrome, DNA,, and, Protein, Synthesis, 7338, Tocris Bioscience

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