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K 579

Cat. No. 2790 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2790 has been discontinued.

View all Dipeptidyl Peptidase IV products.
说明： Dipeptidyl peptidase IV (DPP-IV) inhibitor
化学名： (2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for K 579

K 579 is a dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.

技术数据 for K 579

分子量 328.41
公式 C17H24N6O
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 440100-64-1
PubChem ID 9818824
InChI Key JERPHRNGJBSFAP-AWEZNQCLSA-N
Smiles O=C(CNC2(C)CCN(C3=NC=CC=N3)CC2)N1CCC[C@H]1C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for K 579

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for K 579

参考文献是支持产品生物活性的出版物。

Takasaki et al (2004) K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent. Eur.J.Pharmacol. 486 335 PMID: 14985056

Takasaki et al (2004) Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats. J.Pharmacol.Sci. 95 291 PMID: 15215655

Takasaki et al (2004) Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV. Eur.J.Pharmacol. 505 237 PMID: 15556158

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关键词: K 579, K 579 supplier, Dipeptidyl, peptidase, IV, DPP-IV, inhibitors, inhibits, Peptidase, Proteinases, Proteases, K579, DPP4, (DPP-IV), 2790, Tocris Bioscience

2 篇 K 579 的引用文献

引用文献是使用了 Tocris 产品的出版物。 K 579 的部分引用包括：

Inoue et al (2014) Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats. Dig Dis Sci 59 1286 PMID: 24379150

Fujiwara et al (2015) Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagl. and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration. Arterioscler Thromb Vasc Biol 56 155 PMID: 25759522

K 579 的评论

平均评分: 5 (Based on 1 Review.)

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Treat ulcers in vivo.
By Yasutada Akiba on 01/04/2018
分析类型： In Vivo
种属： Rat

Oral once a day treatment is useful to treat small intestinal ulcer model in rats, because of long half life due to enterohepatic circulation.

PMID: 24379150