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Submit ReviewKF 38789
说明： Selective inhibitor of P-selectin-mediated cell adhesion
化学名： 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
纯度： ≥97% (HPLC)
生物活性 for KF 38789
KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. KF 38789 blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.
化合物库 for KF 38789
KF 38789 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for KF 38789
| 分子量 | 375.44 |
| 公式 | C19H21NO5S |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 257292-29-8 |
| PubChem ID | 5373277 |
| InChI Key | FJDFKOSFDPIMBV-NBVRZTHBSA-N |
| Smiles | COC1=CC=C(C2CC(=NCCS2)C2=C(O)C=C(C)OC2=O)C(OC)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for KF 38789
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 37.54 | 100 |
制备储备液 for KF 38789
以下数据基于产品分子量 375.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.66 mL | 13.32 mL | 26.64 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.33 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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产品说明书 for KF 38789
参考文献 for KF 38789
参考文献是支持产品生物活性的出版物。
Haggerty et al (2000) Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis. Chem.Biol. 7 275 PMID: 10780927
Ohta et al (2001) Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779. Inflamm.Res. 50 544 PMID: 11766994
Kaila et al (2007) Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J.Med.Chem. 50 21 PMID: 17201408
If you know of a relevant reference for KF 38789, please let us know.
关键词: KF 38789, KF 38789 supplier, Selective, inhibitors, inhibits, P-selectin-mediated, cell, adhesio, Adhesion, Molecules, KF38789, Cell, 2748, Tocris Bioscience
3 篇 KF 38789 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KF 38789 的部分引用包括：
Zhao et al (2017) Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice. J Cell Mol Med 21 1523 PMID: 28211187
Neufeld et al (2021) Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment Sci Adv 7 eabi9119 PMID: 34407932
Li et al (2019) Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow. Nat Commun 10 2406 PMID: 31160622
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KF 38789 的评论
平均评分: 5 (Based on 1 Review.)
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We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.
By
Meghan Bradshaw on 02/20/2019
种属： Human
We worked to determine the inhibitory effects of KF 38789 on P-selectin-mediated cell adhesion.KF 38789 shows selective inhibition and works ideally.
