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Submit ReviewL 760735
说明： High affinity NK1 antagonist
化学名： 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for L 760735
L 760735 is a high affinity NK1 receptor antagonist (IC50 = 0.19 nM at human NK1 receptors). Selective (>300-fold) over h-NK2 and h-NK3 receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.
化合物库 for L 760735
L 760735 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for L 760735
| 分子量 | 611.98 |
| 公式 | C26H28F7N5O2.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 188923-01-5 |
| PubChem ID | 9809076 |
| InChI Key | VZBKOBSSEVXFNF-QIRDZIKRSA-N |
| Smiles | FC(C=C3)=CC=[C@@]3[C@@H]1N(CC4=C(CN(C)C)NN=N4)CCO[C@@H]1O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L 760735
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 18.36 | 30 | |
| DMSO | 30.6 | 50 |
制备储备液 for L 760735
以下数据基于产品分子量 611.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.27 mL | 16.34 mL | 32.68 mL |
| 2.5 mM | 0.65 mL | 3.27 mL | 6.54 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.27 mL |
| 25 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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产品说明书 for L 760735
参考文献 for L 760735
参考文献是支持产品生物活性的出版物。
Harrison et al (2001) An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. J.Med.Chem. 44 4296 PMID: 11708932
Duffy et al (2002) Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther 301 536 PMID: 11961054
If you know of a relevant reference for L 760735, please let us know.
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关键词: L 760735, L 760735 supplier, L760735, NK1, antagonists, tachykinin, receptor, antagonist, neurokinin, 1, receptors, substance, P, Receptor, 4013, Tocris Bioscience
1 篇 L 760735 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L 760735 的部分引用包括：
Yin et al (2018) Crystal structure of the human NK1 tachykinin receptor. Proc.Natl.Acad.Sci.U.S.A. 115 13264 PMID: 30538204
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.