主页 / 药理学 / Enzymes / ATPases / H+,K+-ATPase / H+,K+-ATPase Inhibitors / Lansoprazole

Lansoprazole

Cat. No. 2582 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2582 has been discontinued.

View all H<sup>+</sup>,K<sup>+</sup>-ATPase products.
说明： H+,K+-ATPase inhibitor
别名： AG-1749
化学名： 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Lansoprazole

Lansoprazole is a H+,K+-ATPase inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (Cat. No. 2583).

技术数据 for Lansoprazole

分子量 369.36
公式 C16H14F3N3O2S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 103577-45-3
PubChem ID 3883
InChI Key MJIHNNLFOKEZEW-UHFFFAOYSA-N
Smiles CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Lansoprazole

参考文献是支持产品生物活性的出版物。

Satoh et al (1989) Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806 PMID: 2537418

Schmarda et al (2000) The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598 PMID: 10711360

Matheson and Jarvis (2001) Lansoprazole. Drugs 61 1801 PMID: 11693467

按标靶查看相关产品

按产品操作查看相关产品

查看全部 H+,K+-ATPase Inhibitors

关键词: Lansoprazole, Lansoprazole supplier, H+K+-ATPase, inhibitors, inhibits, Hydrogen, Potassium-ATPase, Ion, Transporters, Pumps, ATPases, AG1749, AG-1749, H+,K+-ATPase, 2582, Tocris Bioscience

篇 Lansoprazole 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Lansoprazole 的引用文献。

Lansoprazole 的评论

目前没有该产品的评论。 Be the first to review Lansoprazole and earn rewards!

Have you used Lansoprazole?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review