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LU AA33810

Cat. No. 3562 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent NPY Y5 receptor antagonist
化学名： N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LU AA33810

LU AA33810 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (Ki = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.

化合物库 for LU AA33810

LU AA33810 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LU AA33810

分子量 423.62
公式 C19H25N3O2S3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 304008-29-5
PubChem ID 22254068
InChI Key UWSBTSAJZMIHBL-UHFFFAOYSA-N
Smiles O=S(NC[C@H](CC4)CC[C@@H]4NC1=NC(C2=CC=CC=C2SCC3)=C3S1)(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LU AA33810

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.36 100

制备储备液 for LU AA33810

以下数据基于产品分子量 423.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.8 mL 23.61 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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产品说明书 for LU AA33810

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for LU AA33810

参考文献是支持产品生物活性的出版物。

Walker et al (2009) The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects J.Pharmacol.Exp.Ther. 328 900 PMID: 19098165

If you know of a relevant reference for LU AA33810, please let us know.

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关键词: LU AA33810, LU AA33810 supplier, LUAA33810, potent, NPY, neuropeptide, Y, receptors, Y5, antagonists, neuropeptides, Receptors, 3562, Tocris Bioscience

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