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说明： Allosteric potentiator of α7, α4β2 and α4β4 nAChRs
化学名： [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone
纯度： ≥98% (HPLC)
生物活性 for LY 2087101
LY 2087101 is an allosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.
化合物库 for LY 2087101
LY 2087101 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for LY 2087101
| 分子量 | 318.39 |
| 公式 | C15H11FN2OS2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 913186-74-0 |
| PubChem ID | 11964458 |
| InChI Key | PEAMDZVDNYENPN-UHFFFAOYSA-N |
| Smiles | O=C(C3=CSC=C3)C1=C(C)N=C(NC2=CC=C(F)C=C2)S1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for LY 2087101
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 31.84 | 100 | |
| ethanol | 3.18 | 10 |
制备储备液 for LY 2087101
以下数据基于产品分子量 318.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.7 mL | 31.41 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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产品说明书 for LY 2087101
参考文献 for LY 2087101
参考文献是支持产品生物活性的出版物。
Broad et al (2006) Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J.Pharmacol.Exp.Ther. 318 1108 PMID: 16738207
Young et al (2008) Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 105 14686 PMID: 1879106
If you know of a relevant reference for LY 2087101, please let us know.
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关键词: LY 2087101, LY 2087101 supplier, allosteric, potentiators, modulators, nicotinic, acetylcholine, receptors, nAChRs, alpha7, α7, a7, LY2087101, Nicotinic, (a7), Receptors, (a4b2), (Other, Subtypes), 4141, Tocris Bioscience
1 篇 LY 2087101 的引用文献
引用文献是使用了 Tocris 产品的出版物。 LY 2087101 的部分引用包括：
Haiyang et al (2020) Studying Nicotinic Acetylcholine Receptors Using the IonFlux™ Microfluidic-Based Automated Patch-Clamp System with Continuous Perfusion and Fast Solution Exchange. Curr Protoc Pharmacol 88 e73 PMID: 32068960
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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