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Melphalan

Cat. No. 4619 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4619 has been discontinued.

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说明： DNA alkylating agent; cytotoxic and antineoplastic
化学名： 4-[Bis(2-Chloroethyl)amino]-L-phenylalanine
纯度： ≥95% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Melphalan

Melphalan is a DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).

技术数据 for Melphalan

分子量 305.2
公式 C13H18Cl2N2O2
储存 Store at RT
纯度 ≥95% (HPLC)
CAS Number 148-82-3
PubChem ID 460612
InChI Key SGDBTWWWUNNDEQ-LBPRGKRZSA-N
Smiles ClCCN(CCCl)C1=CC=C(C[C@H](N)C(O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Melphalan

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Melphalan

参考文献是支持产品生物活性的出版物。

Blumberg et al (1965) An alkylating agent for multiple myeloma: melp. JAMA. 191 547 PMID: 14239026

Merck Index 12 5872

Bauer and Povirk (1997) Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 25 1211 PMID: 9092631

Mougenot et al (2006) In vitro cytotoxic effect of melp. and pilot phase II study in hormone-refractory prostate cancer. Anticancer Res. 26 2197 PMID: 16821586

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关键词: Melphalan, Melphalan supplier, antineoplastics, alkylating, DNA, agents, chemotherapeutics, cytotoxic, crosslinks, Other, Apoptosis, 4619, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Melphalan, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

2 篇 Melphalan 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Melphalan 的部分引用包括：

Carlos et al (2019) Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. EMBO Mol Med 11 e9982 PMID: 31273933

Carlos et al (2019) Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. EMBO Mol Med PMID: 31127019

Melphalan 的评论

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Melphalan

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.