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Methylene Blue

Cat. No. 3213 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3213 has been discontinued.

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说明： Biological stain; also neuroprotective and antimalarial
化学名： 3,7-bis(Dimethylamino)phenazathionium chloride
说明书
引用文献
评论 (1)
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Methylene Blue

Methylene Blue is a biological stain and redox indicator. Methylene blue inhibits monoamine oxidase A, tau filament formation and nitric oxide synthase (IC50 values = 0.07 μM, 1.9 μM and 5.3 μM, respectively), and inhibits guanylate cyclase. Methylene Blue delays senescence and stimulates proliferation of fibroblasts and skin cells. In vitro, Methylene Blue promotes wound healing, upregulates elastin expression and production, increases synthesis of heme, is neuroprotective (EC50 = 0.18 nM) and rescues the loss of dopaminergic neurons induced by Rotenone (Cat. No. 3616). Also antimalarial.

技术数据 for Methylene Blue

分子量 319.85
公式 C16H18ClN3S
储存 Store at RT
CAS Number 61-73-4
PubChem ID 6099
InChI Key CXKWCBBOMKCUKX-UHFFFAOYSA-M
Smiles CN(C)C1=CC=C2C(SC(C3=N2)=C/C(C=C3)=[N+](C)/C)=C1.[Cl-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Methylene Blue

参考文献是支持产品生物活性的出版物。

Hwang et al (1998) Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br.J.Pharmacol. 125 1158 PMID: 9863642

Taniguchi et al (2005) Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J.Biol.Chem. 280 7614 PMID: 15611092

Wischik et al (1996) Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Proc.Natl.Acad.Sci.U.S.A. 93 11213 PMID: 8855335

Atamna et al (2008) Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB J. 22 703 PMID: 17928358

Mayer et al (1993) Inhibition of nitric oxide synthesis by methylene blue. Biochem.Pharmacol. 45 367 PMID: 7679577

Poteet et al (2012) Neuroprotective actions of methylene blue and its derivatives. PLoS One 7 PMID: 23118969

Wen et al (2011) Alternative mitochondrial electron transfer as a novel strategy for neuroprotection. J.Biol.Chem. 286 16504 PMID: 21454572

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关键词: Methylene Blue, Methylene Blue supplier, Biological, stain, Soluble, guanylyl, cyclases, inhibitors, inhibits, tau, filaments, aggregation, Reagents, sGC, Tubulin, Microtubules, Nitric, Oxide, Signaling, Signalling, fibrils, senescence, wound, healing, antimalarial, neuroprotective, dopaminergic, proliferative, prolifera, Guanylyl, Cyclase, Other, Mitosis, Labels, and, Stains, Histology, Antimalarials, Stem, Cell, Proliferation, 3213, Tocris Bioscience

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Methylene blue was used to prepare Eosin Methylene Blue agar plate.
By Anonymous on 11/13/2018
种属： Human

Methylene blue was used to prepare Eosin Methylene Blue (EMB) agar plate. Excellent product.

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

  • Fluorescent Dyes, including dyes for flow cytometry
  • Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
  • Tissue Clearing Kits and Reagents
  • Aptamer-based RNA Imaging Reagents
  • Fluorescent Probes for Imaging Bacteria
  • TSA VividTM Fluorophore Kits
  • TSA Reagents for Enhancing IHC, ICC & FISH Signals