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MG 101

Cat. No. 3358 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Calpain inhibitor; activates p53-dependent apoptosis
别名： Calpain inhibitor-1
化学名： N-Acetyl-L-leucine-L-leucine-L-norleucinal
说明书
引用文献 (1)
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for MG 101

Calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.

技术数据 for MG 101

分子量 383.53
公式 C20H37N3O4
储存 Store at -20°C
CAS Number 110044-82-1
PubChem ID 443118
InChI Key FMYKJLXRRQTBOR-BZSNNMDCSA-N
Smiles CCCC[C@H](NC([C@@H](N[C@@]([C@H](CC(C)C)NC(C)=O)=O)CC(C)C)=O)C=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for MG 101

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化学品安全技术说明书

参考文献 for MG 101

参考文献是支持产品生物活性的出版物。

Atencio et al (2000) Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines. Cell Growth Differ. 11 247 PMID: 10845425

Chatterjee et al (2001) Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59 2073 PMID: 11380809

Sherwood et al (1993) In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc.Natl.Acad.Sci.USA 90 3353

Perrin et al (2002) In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cell Mol.Biol. 48 OL267

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关键词: MG 101, MG 101 supplier, Calpain, inhibitors, inhibits, Proteinases, Proteases, MG101, inhibitor-1, Calpains, Calcium-Sensitive, 3358, Tocris Bioscience

1 篇 MG 101 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MG 101 的部分引用包括：

Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092 PMID: 27554194

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets

Pathways for MG 101

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.