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MI 2 (MALT1 inhibitor)

Cat. No. 4848 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： MALT1 inhibitor
化学名： 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MI 2 (MALT1 inhibitor)

MI 2 (MALT1 inhibitor) is a MALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.

技术数据 for MI 2 (MALT1 inhibitor)

分子量 455.72
公式 C19H17Cl3N4O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1047953-91-2
PubChem ID 45942672
InChI Key TWJGQZBSEMDPQP-UHFFFAOYSA-N
Smiles O=C(CCl)NC(C=C3)=CC=C3N1C(C2=CC(Cl)=C(Cl)C=C2)=NC(OCCOC)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MI 2 (MALT1 inhibitor)

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.57 100
ethanol 9.11 20

制备储备液 for MI 2 (MALT1 inhibitor)

以下数据基于产品分子量 455.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.97 mL 21.94 mL
5 mM 0.44 mL 2.19 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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产品说明书 for MI 2 (MALT1 inhibitor)

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参考文献 for MI 2 (MALT1 inhibitor)

参考文献是支持产品生物活性的出版物。

Fontan et al (2012) MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 22 812 PMID: 23238016

If you know of a relevant reference for MI 2 (MALT1 inhibitor), please let us know.

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关键词: MI 2 (MALT1 inhibitor), MI 2 (MALT1 inhibitor) supplier, MI2, MALT, 1, inhibitors, inhibits, NF-KB, NFKB, NF, Kappa, B, NFκB, lymphoma, ABC-DLBCL, Other, Proteases, 4848, Tocris Bioscience

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A MALT1 Protease Inhibitor that works really well.
By Anonymous on 12/08/2019
分析类型： In Vitro
种属： Human
细胞系/组织： MDA231, U2OS

MALT1 protease inhibitor MI-2 suppress RelB cleavage in a dose-dependent manner in U2OS osteosarcoma cells. Cells were pretreated with increasing concentration of MI2 inhibitor (0.25, 0.5, 1, or 2 µM) for 1 h prior to stimulation with 2 U/mL thrombin for an additional 3 h. MDA-MB-231 cells stimulated with thrombin also show evidence of RelB cleavage that is suppressed by MI-2 (2 μM).

PMID: 31420608 参考文献
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