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Minocycline hydrochloride

Cat. No. 3268 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Antibiotic. Displays neuroprotective effects
化学名： [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
实验方案 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Minocycline hydrochloride

Minocycline hydrochloride is a tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant. Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), (S)-(+)-Dimethindene maleate (Cat.No. 1425) and human leukemia inhibitory factor.

For more information about how Minocycline hydrochloride may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).

技术数据 for Minocycline hydrochloride

分子量 493.94
公式 C23H27N3O7.HCl
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 13614-98-7
PubChem ID 54685925
InChI Key WTJXVDPDEQKTCV-VQAITOIOSA-N
Smiles NC(C4=C(O)[C@@H](N(C)C)[C@@]3([H])[C@](C4=O)(O)C(O)=C2C(C1=C(O)C=CC(N(C)C)=C1C[C@]([H])2C3)=O)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Minocycline hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.39 100
water 12.35 25

制备储备液 for Minocycline hydrochloride

以下数据基于产品分子量 493.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.12 mL 20.25 mL
5 mM 0.4 mL 2.02 mL 4.05 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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产品说明书 for Minocycline hydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Minocycline hydrochloride

参考文献是支持产品生物活性的出版物。

Tikka et al (2001) MinCyc, a tetracy. derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J.Neurosci. 21 2580 PMID: 11306611

Brundula et al (2002) Targeting leukocyte MMPs and transmigration: MinCyc as a potential therapy for multiple sclerosis. Brain 125 1297 PMID: 12023318

Padi and Kulkarni (2008) MinCyc prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms. Eur.J.Pharmacol. 601 79 PMID: 18952075

Yang et al (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell. 169 243 PMID: 28388409

If you know of a relevant reference for Minocycline hydrochloride, please let us know.

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关键词: Minocycline hydrochloride, Minocycline hydrochloride supplier, Minocycline, HCl, antibiotics, MMP, matrix, metalloproteinase, inhibitors, inhibits, neuroprotective, Antibiotics, Matrix, Metalloprotease, Stem, Cell, Reprogramming, 3268, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Minocycline hydrochloride (internal use), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

2 篇 Minocycline hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Minocycline hydrochloride 的部分引用包括：

Yaeger and Trussell (2015) Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci 35 4741 PMID: 25788690

Song et al (2015) MinCyc does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Hum Mol Genet 11 25 PMID: 25933605

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Minocycline hydrochloride 的评论

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Blocker of microglia reactivity.
By Luiz Alexandre Magno on 07/16/2018
分析类型： In Vivo
种属： Mouse
细胞系/组织： Brain

I have used the antibiotic minocycline to impair activation of microglia in the brain of mice. This drug has anti-inflammatory properties that block microglial reactivity, which can be easily confirmed by expression of the CD68 protein. The drug was diluted in PBS and injected i.p. (75 mg/kg) in mice, twice a day, for 7 days. The image shows that microglial cells (stained for Iba1) do not express CD68 (in red) after treatment with minocycline.

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Minocycline hydrochloride 实验方案

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