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Mitochondrial fusion promoter M1

Cat. No. 6898 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Mitochondrial fusion promoter
化学名： 4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Mitochondrial fusion promoter M1

Mitochondrial fusion promoter M1 is a mitochondrial fusion promoter. Protects cells from mitochondrial fragmentation-associated cell death. Induces mitochondrial fusion in effector T cells imposing a memory T cell morphology. Improves cellular respiration and potentiates glucose-stimulated insulin-secretion in cholesterol-exposed pancreatic β cells. Mitochondrial fusion promoter M1 also enhances mitochondrial dynamics and transport velocity in axons of the sciatic nerve in vitro and enhances axon regeneration in the optic nerve in an in vivo model of nerve damage.

技术数据 for Mitochondrial fusion promoter M1

分子量 364.05
公式 C14H10Cl4N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 219315-22-7
PubChem ID 136672588
InChI Key CYVDGZYJHHYIIU-GXHLCREISA-N
Smiles C\C(=N/NC1=C(Cl)C=C(Cl)C=C1Cl)C1=C(O)C=CC(Cl)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Mitochondrial fusion promoter M1

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Mitochondrial fusion promoter M1

参考文献是支持产品生物活性的出版物。

Asalla et al (2016) Restoring mitochondrial function: a small molecule-mediated approach to enhance glucose stimulated insulin secretion in cholesterol accumulated pancreatic beta cells. Sci.Rep. 10 27513 PMID: 27282931

Wang et al (2012) A small molecule promotes mitochondrial fusion in mammalian cells. Angew.Chem.Int.Ed.Engl. 51 9302 PMID: 22907892

Buck et al (2016) Mitochondrial dynamics controls T cell fate through metabolic programming. Cell 166 63 PMID: 27293185

Au et al (2022) A small molecule M1 promotes optic nerve regeneration to restore target-specific neural activity and visual function. Proc.Natl.Acad.Sci.USA 119 e2121273119 PMID: 36306327

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关键词: Mitochondrial fusion promoter M1, Mitochondrial fusion promoter M1 supplier, mitochondrial, fusion, promoters, promotes, cellular, respiration, mitochondrion, Oxidative, Phosphorylation, Other, Apoptosis, 6898, Tocris Bioscience

1 篇 Mitochondrial fusion promoter M1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mitochondrial fusion promoter M1 的部分引用包括：

Dan et al (2022) Aspartate Alleviates Colonic Epithelial Damage by Regulating Intestinal Stem Cell Proliferation and Differentiation via Mitochondrial Dynamics. Mol Nutr Food Res 66 e2200168 PMID: 36310136

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