MK 1903

Cat. No. 4622 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective GPR109A (HCA₂) agonist

化学名： (4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2]pyrazole-3-carboxylic acid

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MK 1903

MK 1903 is a potent and selective hydroxycarboxylic acid receptor 2 (HCA₂, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC₅₀ values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.

化合物库 for MK 1903

MK 1903 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for MK 1903

分子量	164.16
公式	C₈H₈N₂O₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1268882-43-4
PubChem ID	49763030
InChI Key	CUTZNERBKDMLAP-QWWZWVQMSA-N
Smiles	[H][C@@]12CC3=C(NN=C3C(O)=O)[C@@]([H])1C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MK 1903

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	16.42	100
	ethanol	8.21	50

制备储备液 for MK 1903

以下数据基于产品分子量 164.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	6.09 mL	30.46 mL	60.92 mL
5 mM	1.22 mL	6.09 mL	12.18 mL
10 mM	0.61 mL	3.05 mL	6.09 mL
50 mM	0.12 mL	0.61 mL	1.22 mL

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产品说明书 for MK 1903

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MK 1903

参考文献是支持产品生物活性的出版物。

Boatman (2012) (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[α]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J.Med.Chem. 55 3644 PMID: 22435740

Lauring (2012) Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci.Transl.Med. 4 148ra115 PMID: 22914621

If you know of a relevant reference for MK 1903, please let us know.

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Hydroxycarboxylic Acid Receptors

关键词: MK 1903, MK 1903 supplier, MK1903, HCA2, hydroxycarboxylic, acid, receptors, GPR109A, HM74A, agonists, Hydroxycarboxylic, Acid, Receptors, 4622, Tocris Bioscience