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ML 130

Cat. No. 4354 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4354 has been discontinued.

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说明： Inhibits NOD1-induced NF-κB activation
化学名： 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine
纯度： ≥99% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for ML 130

ML 130 is a potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein in vitro.

化合物库 for ML 130

ML 130 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 130

分子量 287.34
公式 C14H13N3O2S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 799264-47-4
PubChem ID 1088438
InChI Key SRFABRWQVPCPRG-UHFFFAOYSA-N
Smiles NC2=NC1=CC=CC=C1N2S(=O)(C3=CC=C(C)C=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for ML 130

参考文献是支持产品生物活性的出版物。

Correa et al (2011) Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chem.Biol. 18 825 PMID: 21802003

Khan et al (2011) Identification of inhibitors of NOD1-induced nuclear factor-κB activation. ACS Med.Chem.Lett. 2 780 PMID: 22003428

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关键词: ML 130, ML 130 supplier, ML130, nf-kb, nf-kappab, nf-μb, inhibitors, inhibits, NOD1, nucleotide-binding, oligomerization, domain, 1, selective, potent, NF-kB/IkB, 4354, Tocris Bioscience

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Pathways for ML 130

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.