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ML 210

Cat. No. 6429 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
化学名： [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (4)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 210

ML 210 is a glutathione peroxidase (GPX4) inhibitor. Kills mutant RAS-expressing cell lines (IC50 values are 71 and 272 nM for HRAS G12v mutant expressing cell lines BJeLR and BJeH-LT, respectively). Exhibits 4-fold selectivity for HRAS mutant-expressing cell lines. Induces ferroptosis in tumor initiation "persister" cells and drug-resistant tumor cells.

化合物库 for ML 210

ML 210 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 210

分子量 475.32
公式 C22H20Cl2N4O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1360705-96-9
PubChem ID 49766530
InChI Key VIBHJPDPEVVDTB-UHFFFAOYSA-N
Smiles CC1=C([N+]([O-])=O)C(C(N2CCN(C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)CC2)=O)=NO1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 210

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.77 50

制备储备液 for ML 210

以下数据基于产品分子量 475.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.21 mL 21.04 mL 42.08 mL
2.5 mM 0.84 mL 4.21 mL 8.42 mL
5 mM 0.42 mL 2.1 mL 4.21 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

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产品说明书 for ML 210

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ML 210

参考文献是支持产品生物活性的出版物。

Weïwer et al (2012) Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg.Med.Chem.Lett. 22 1822 PMID: 22297109

Yang et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156 317 PMID: 24439385

Hangauer et al (2017) Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature 551 247 PMID: 29088702

If you know of a relevant reference for ML 210, please let us know.

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关键词: ML 210, ML 210 supplier, ML210, Glutathione, peroxidases, GPX4, inhibitors, inhibits, synthetically, lethal, compounds, mutant, RAS, HRAS, ferroptosis, tumor, initiation, cells, persister, drug, resistant, TICs, Ras, GTPases, Ferroptosis, Cancer, Stem, Cells, 6429, Tocris Bioscience

1 篇 ML 210 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ML 210 的部分引用包括：

Jeff et al (2020) Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. Elife 9 PMID: 32686647

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

RAS Oncoproteins Scientific Review

RAS Oncoproteins Scientific Review

Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Pathways for ML 210

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.
MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.