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ML 297

Cat. No. 5380 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective Kir3.1/3.2 (GIRK1/2) channel activator
化学名： N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 297

ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.

许可信息

Sold under license from Vanderbilt University

化合物库 for ML 297

ML 297 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 297

分子量 328.32
公式 C17H14F2N4O
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 1443246-62-5
PubChem ID 56642816
InChI Key IEKSMUSSYJUQMY-UHFFFAOYSA-N
Smiles O=C(NC2=CC(C)=NN2C3=CC=CC=C3)NC1=CC(F)=C(F)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 297

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.83 100
ethanol 16.42 50

制备储备液 for ML 297

以下数据基于产品分子量 328.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.23 mL 30.46 mL
5 mM 0.61 mL 3.05 mL 6.09 mL
10 mM 0.3 mL 1.52 mL 3.05 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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参考文献 for ML 297

参考文献是支持产品生物活性的出版物。

Kaufmann et al (2013) ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem.Neurosci. 4 1278 PMID: 23730969

Wen et al (2013) Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg.Med.Chem.Lett. 23 4562 PMID: 23838260

If you know of a relevant reference for ML 297, please let us know.

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关键词: ML 297, ML 297 supplier, ML297, selective, Kir3.1, GIRK1, channels, activators, inward, rectifying, rectifiers, potassium, K+, epilepsy, Inward, rectifier, Potassium, Channels, 5380, Tocris Bioscience

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ML 297 的评论

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ML 297 worked ideally and the data obtained with the product was consistent throughout the study.
By Anonymous on 10/31/2018
分析类型： In Vitro
种属： Human

ML 297 and ML 277 was used on our University labs to understand potassium channel activation percentage at increasing concentrations. ML 297 worked ideally and the data obtained with the product was consistent throughout the experiment.

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