主页 / 药理学 / Enzymes / Proteases / Deubiquitinating Enzymes / Deubiquitinating Enzyme Inhibitors / ML 323

ML 323

Cat. No. 6435 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective USP1-UAF1 allosteric inhibitor
化学名： 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 323

ML 323 is a potent and selective allosteric inhibitor of USP1-UAF1 deubiquitinase complex (IC50 = 76 nM). Exhibits selectivity for USP1-UAF1 over a panel of enzymes, including other deuquitinating enzymes. Inhibits deubiquitination of PCNA and FANCD2 and sensitizes cisplatin-resistant H596 cells to cell death induced by cisplatin (Cat. No. 2251) in vitro.

化合物库 for ML 323

ML 323 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 323

分子量 384.48
公式 C23H24N6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1572414-83-5
PubChem ID 60167849
InChI Key VUIRVWPJNKZOSS-UHFFFAOYSA-N
Smiles CC(C)C1=C(C=CC=C1)C1=NC=C(C)C(NCC2=CC=C(C=C2)N2C=CN=N2)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 323

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.45 100
ethanol 38.45 100

制备储备液 for ML 323

以下数据基于产品分子量 384.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.6 mL 13 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for ML 323

参考文献是支持产品生物活性的出版物。

Liang et al (2014) A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat.Chem.Biol. 10 298 PMID: 24531842

If you know of a relevant reference for ML 323, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Deubiquitinating Enzyme Inhibitors

关键词: ML 323, ML 323 supplier, ML323, DUB, inhibitors, inhibits, deubiquitinase, USP1, UAF1, potent, selective, Deubiquitinating, Enzymes, 6435, Tocris Bioscience

篇 ML 323 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 ML 323 的引用文献。 您是否知道使用了 Tocris ML 323 的优秀论文？ 请告知我们.

ML 323 的评论

目前没有该产品的评论。 Be the first to review ML 323 and earn rewards!

Have you used ML 323?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review