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ML 418

Cat. No. 6889 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Kir 7.1 inhibitor; also inhibits Kir 6.2
化学名： Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 418

ML 418 is a Kir7.1 inhibitor (IC50 = 0.31 μM). Also inhibits Kir6.2 with similar potency. Displays >17-fold selectivity for Kir7.1 over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 and Kir4.1. Active in vivo.

化合物库 for ML 418

ML 418 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 418

分子量 377.87
公式 C19H24CIN3O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1928763-08-9
PubChem ID 91667465
InChI Key CWIXCQOSULUGBT-UHFFFAOYSA-N
Smiles CC(OC(NC1CCN(CC1)CC2=C(C3=C(C(Cl)=C2)C=CC=N3)O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 418

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.56 20

制备储备液 for ML 418

以下数据基于产品分子量 377.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 13.23 mL 66.16 mL 132.32 mL
1 mM 2.65 mL 13.23 mL 26.46 mL
2 mM 1.32 mL 6.62 mL 13.23 mL
10 mM 0.26 mL 1.32 mL 2.65 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for ML 418

参考文献是支持产品生物活性的出版物。

Swale et al (2016) ML418: the first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. ACS Chem.Neurosci. 7 1013 PMID: 27184474

Kharade (2017) Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by small-molecule inhibitor VU590. Mol.Pharmacol. 92 338 PMID: 28619748

If you know of a relevant reference for ML 418, please let us know.

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关键词: ML 418, ML 418 supplier, ML418, inward-rectifier, potassium, channels, Kir, 7.1, 6.2, inhibitors, inhibits, active, in, vivo, Inward, rectifier, Potassium, Channels, 6889, Tocris Bioscience

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