Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMLS 1547
说明： G protein-biased D2 partial agonist
化学名： 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol
纯度： ≥98% (HPLC)
生物活性 for MLS 1547
MLS 1547 is a G protein-biased D2 receptor partial agonist (Ki = 1.2 μM). Stimulates D2 receptor G protein-mediated signaling and acts as an antagonist of dopamine-mediated β-arrestin recruitment at D2 receptors.
化合物库 for MLS 1547
MLS 1547 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for MLS 1547
| 分子量 | 354.83 |
| 公式 | C19H19ClN4O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 315698-36-3 |
| PubChem ID | 1093278 |
| InChI Key | OPEJNANYABTIGC-UHFFFAOYSA-N |
| Smiles | OC1=C(C=C(C2=C1N=CC=C2)Cl)CN3CCN(C4=CC=CC=N4)CC3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MLS 1547
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 35.48 | 100 |
制备储备液 for MLS 1547
以下数据基于产品分子量 354.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.09 mL | 28.18 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for MLS 1547
参考文献 for MLS 1547
参考文献是支持产品生物活性的出版物。
Free et al (2014) Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 DA receptor. Mol.Pharmacol. 86 96 PMID: 24755247
If you know of a relevant reference for MLS 1547, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: MLS 1547, MLS 1547 supplier, MLS1547, dopamine, D2, DA, partial, agonists, agonism, G, protein, biased, signaling, Receptors, 6171, Tocris Bioscience
2 篇 MLS 1547 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MLS 1547 的部分引用包括：
Stefan et al (2021) New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling. Sci Rep 11 8288 PMID: 33859231
Ting et al (2021) Exploiting D2 receptor β-arrestin2-biased signalling to suppress tumour growth of pituitary adenomas. Br J Pharmacol 178 3570-3586 PMID: 33904172
您是否知道使用了 Tocris MLS 1547 的优秀论文？ 请告知我们.
MLS 1547 的评论
目前没有该产品的评论。 Be the first to review MLS 1547 and earn rewards!
Have you used MLS 1547?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.