MOG (35-55)

Cat. No. 2568 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Encephalitogenic myelin oligodendrocyte glycoprotein fragment

纯度： ≥95% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MOG (35-55)

MOG (35-55) or myelin oligodendrocyte glycoprotein (MOG) 35-55 is a minor component of CNS myelin. MOG (35-55) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination, common to the manifestations of multiple sclerosis. MOG (35-55) induces strong T and B cell responses and is highly encephalitogenic. MOG (35-55) induces T cell-mediated multiple sclerosis in animal models. When co-administered with ITE, MOG (35-55) induces tolerogenic dendritic cells and suppresses disease development in mouse preclinical models of multiple sclerosis.

技术数据 for MOG (35-55)

分子量	2581.97
公式	C₁₁₈H₁₇₇N₃₅O₂₉S
序列	MEVGWYRSPFSRVVHLYRNGK
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	149635-73-4
PubChem ID	24868190
InChI Key	JMTCEFUSRHYJBF-DDJPMISGSA-N
Smiles	[H]N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MOG (35-55)

溶解性	Soluble to 0.50 mg/ml in water

产品说明书 for MOG (35-55)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MOG (35-55)

参考文献是支持产品生物活性的出版物。

Ichikawa et al (1996) Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J.Immunol. 157 919 PMID: 8752946

Slavin et al (1998) Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity 28 109 PMID: 9771980

Zhang et al (2004) T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6xSJL) F1 mice. J.Neuroimmunol. 148 1 PMID: 14975581

Kenison et al (2020) Tolerogenic nanoparticles suppress central nervous system inflammation. Proc.Natl.Acad.Sci.U.S.A. 117 32017 PMID: 33239445

Miyamura et al (2019) Myelin oligodendrocyte glycoprotein 35-55 (MOG 35-55)-induced experimental autoimmune encephalomyelitis: a model of chronic multiple sclerosis. Bio.Protoc. 9 e3453 PMID: 33654948

If you know of a relevant reference for MOG (35-55), please let us know.

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关键词: MOG (35-55), MOG (35-55) supplier, Encephalitogenic, myelin, oligodendrocyte, glycoprotein, fragment, Neuronal, Metabolism, 2568, Tocris Bioscience

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