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Submit ReviewMOG (35-55) or myelin oligodendrocyte glycoprotein (MOG) 35-55 is a minor component of CNS myelin. MOG (35-55) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination, common to the manifestations of multiple sclerosis. MOG (35-55) induces strong T and B cell responses and is highly encephalitogenic. MOG (35-55) induces T cell-mediated multiple sclerosis in animal models. When co-administered with ITE, MOG (35-55) induces tolerogenic dendritic cells and suppresses disease development in mouse preclinical models of multiple sclerosis.
分子量 | 2581.97 |
公式 | C118H177N35O29S |
序列 | MEVGWYRSPFSRVVHLYRNGK |
储存 | Store at -20°C |
纯度 | ≥95% (HPLC) |
CAS Number | 149635-73-4 |
PubChem ID | 24868190 |
InChI Key | JMTCEFUSRHYJBF-DDJPMISGSA-N |
Smiles | [H]N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
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溶解性 | Soluble to 0.50 mg/ml in water |
参考文献是支持产品生物活性的出版物。
Ichikawa et al (1996) Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J.Immunol. 157 919 PMID: 8752946
Slavin et al (1998) Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity 28 109 PMID: 9771980
Zhang et al (2004) T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6xSJL) F1 mice. J.Neuroimmunol. 148 1 PMID: 14975581
Kenison et al (2020) Tolerogenic nanoparticles suppress central nervous system inflammation. Proc.Natl.Acad.Sci.U.S.A. 117 32017 PMID: 33239445
Miyamura et al (2019) Myelin oligodendrocyte glycoprotein 35-55 (MOG 35-55)-induced experimental autoimmune encephalomyelitis: a model of chronic multiple sclerosis. Bio.Protoc. 9 e3453 PMID: 33654948
If you know of a relevant reference for MOG (35-55), please let us know.
关键词: MOG (35-55), MOG (35-55) supplier, Encephalitogenic, myelin, oligodendrocyte, glycoprotein, fragment, Neuronal, Metabolism, 2568, Tocris Bioscience
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