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Submit ReviewMosapride citrate
说明： 5-HT4 agonist and 5-HT3 antagonist
化学名： 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamide citrate
纯度： ≥99% (HPLC)
生物活性 for Mosapride citrate
Mosapride citrate is a 5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2, α1, α2, 5-HT1 and 5-HT2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.
技术数据 for Mosapride citrate
| 分子量 | 614.02 |
| 公式 | C21H25ClFN3O3.C6H8O7 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 112885-42-4 |
| PubChem ID | 119583 |
| InChI Key | HUZTYZBFZKRPFG-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)(CC(O)=O)CC(O)=O.ClC1=C(N)C=C(OCC)C(C(NCC2OCCN(CC3=CC=C(F)C=C3)C2)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Mosapride citrate
参考文献 for Mosapride citrate
参考文献是支持产品生物活性的出版物。
Yoshida et al (1989) AS-4370, a novel gastrokinetic agent free of DA D2 receptor antagonist properties. Arch.Int.Pharmacodyn.Ther. 300 51 PMID: 2533479
Mine et al (1997) Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J.Pharmacol.Exp.Ther. 283 1000 PMID: 9399969
Yoshida et al (1993) Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals. Arzneim.-Forsch. 43 1078
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关键词: Mosapride citrate, Mosapride citrate supplier, 5-HT3, antagonists, 5-HT4, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 2844, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.