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MPro N3

Cat. No. 7230 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Coronavirus Mpro inhibitor
化学名： N-[(5-Methyl-3-isoxazolyl)carbonyl]-L-alanyl-L-valyl-N-[(1S,2E)-4-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-4-(phenylmethoxy)-2-buten-1-yl]-L-leucinamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MPro N3

MPro N3 is a coronavirus main protease (Mpro) inhibitor (respective IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibits SARS-CoV-2 viral cell entry in a plaque reduction assay (IC50 = 16.8 μM).

化合物库 for MPro N3

MPro N3 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for MPro N3

分子量 680.8
公式 C35H48N6O8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 884650-98-0
PubChem ID 6323191
InChI Key IDBWWEGDLCFCTD-VNEMRZQUSA-N
Smiles CC(C[C@@H](C(N[C@H](/C=C/C(OCC1=CC=CC=C1)=O)C[C@@H]2CCNC2=O)=O)NC([C@H](C(C)C)NC([C@@H](NC(C3=NOC(C)=C3)=O)C)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MPro N3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.04 50

制备储备液 for MPro N3

以下数据基于产品分子量 680.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 2.94 mL 14.69 mL 29.38 mL
2.5 mM 0.59 mL 2.94 mL 5.88 mL
5 mM 0.29 mL 1.47 mL 2.94 mL
25 mM 0.06 mL 0.29 mL 0.59 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for MPro N3

参考文献是支持产品生物活性的出版物。

Yang et al (2005) Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS.One. 10 PMID: 16128623

Jin et al (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 582 289 PMID: 32272481

If you know of a relevant reference for MPro N3, please let us know.

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关键词: MPro N3, MPro N3 supplier, MProN3, coronavirus, main, protease, proteinase, inhibitors, inhibits, Mpro, 3CLpro, MHV-A29,, HCoV-229E, FOPV, SARS-CoV, SARS-CoV-2, 3C, and, 3CL, Proteases, Coronavirus, 7230, Tocris Bioscience

1 篇 MPro N3 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MPro N3 的部分引用包括：

Ghislaine et al (2021) Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates. Nat Commun 12 6786 PMID: 34811361

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