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Submit ReviewVery potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.
分子量 | 401.56 |
公式 | C19H35N3O4S |
储存 | Store at -20°C |
CAS Number | 145757-50-2 |
PubChem ID | 4331 |
InChI Key | RJWLAIMXRBDUMH-UHFFFAOYSA-N |
Smiles | O=C(C)NC(C(NC(C(NC(C([H])=O)CCSC)=O)CC(C)C)=O)CC(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Francis et al (1997) Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 272 14961 PMID: 9169469
Sasaki et al (1990) Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195 PMID: 2079636
关键词: N-Acetyl-L-leucyl-L-leucyl-L-methional, N-Acetyl-L-leucyl-L-leucyl-L-methional supplier, Cathepsin, L, B, inhibitors, inhibits, Proteinases, Proteases, Acetylleucylleucylmethional, 136632-32-1, Calcium-Sensitive, 0384, Tocris Bioscience
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