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Submit ReviewNateglinide
说明： Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels
别名： A-4166,Senaglinide
化学名： N-[[4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine
生物活性 for Nateglinide
Nateglinide is a kir6 (KATP) blocker. Exhibits in vitro tissue selectivity for pancreatic β-cell-type Kir6 channels over cardiovascular Kir6 channels; displays high affinity for SUR1/Kir6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic β-cells by increasing cytosolic Ca2+ concentration. Also agonist at the orphan receptor MRGPRX4.
化合物库 for Nateglinide
Nateglinide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Nateglinide
| 分子量 | 317.42 |
| 公式 | C19H27NO3 |
| 储存 | Store at RT |
| CAS Number | 105816-04-4 |
| PubChem ID | 5311309 |
| InChI Key | OELFLUMRDSZNSF-OFLPRAFFSA-N |
| Smiles | O=[C@](N[C@@H](C(O)=O)CC2=CC=CC=C2)[C@H]1CC[C@H]([C@H](C)C)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Nateglinide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 31.74 | 100 |
制备储备液 for Nateglinide
以下数据基于产品分子量 317.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.75 mL | 31.5 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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产品说明书 for Nateglinide
参考文献 for Nateglinide
参考文献是支持产品生物活性的出版物。
Shinkai et al (1989) N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of hypoglycemic agents. J.Med.Chem. 32 1436 PMID: 2738878
Fujitani et al (1997) The ability of a new hypoglycemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic beta-cells under metabolic inhibition. Br.J.Pharmacol. 120 1191 PMID: 9105692
Hu et al (1999) Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and β-cell KATP channels. J.Pharmacol.Exp.Ther. 291 1372 PMID: 10565863
Chachin et al (2003) Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic β-cell-type KATP channels. J.Pharmacol.Exp.Ther. 304 1025 PMID: 12604678
Kroeze et al (2015) PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nat.Struct.Mol.Biol. 22 362 PMID: 25895059
If you know of a relevant reference for Nateglinide, please let us know.
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